Nucleation of neutral iodine particles has recently been found to involve both iodic acid (HIO₃) and iodous acid (HIO₂). However, the precise role of HIO₂ in iodine oxoacid nucleation remains unclear. Herein, we probe such role by investigating the cluster formation mechanisms and kinetics of (HIO₃)_m(HIO₂)_n (m = 0-4, n = 0-4) clusters with quantum chemical calculations and atmospheric cluster dynamics modeling. When compared with HIO₃, we find that HIO₂ binds more strongly with HIO₃ and also more strongly with HIO₂. After accounting for ambient vapor concentrations, the fastest nucleation rate is predicted for mixed HIO₃-HIO₂ clusters rather than for pure HIO₃ or HIO₂ ones. Our calculations reveal that the strong binding results from HIO₂ exhibiting a base behavior (accepting a proton from HIO₃) and forming stronger halogen bonds. Moreover, the binding energies of (HIO₃)_m(HIO₂)_n clusters show a far more tolerant choice of growth paths when compared with the strict stoichiometry required for sulfuric acid-base nucleation. Our predicted cluster formation rates and dimer concentrations are acceptably consistent with those measured by the CLOUD experiment. This study suggests that HIO₂ could facilitate the nucleation of other acids beyond HIO₃ in regions where base vapors such as ammonia or amines are scarce.