Hydrothermal vent is a unique habitat in the deep sea. It is reported that there are more than 721 known hydrothermal regions in the world, which are widely distributed in mid ocean ridges, back arc basins and volcanic arcs. Deep sea hydrothermal vents are usually in a high-temperature and anoxic environment and rich in reducing compounds. The hydrothermal fluid is mixed with low-temperature oxygenated seawater, resulting in the imbalance of chemical reaction between reducing hydrothermal fluid and oxidized seawater. Hydrothermal autotrophic microorganisms can use the energy generated by reduced substances such as sulfur, hydrogen, methane, sulfide and iron to fix carbon, thus supporting the whole hydrothermal ecosystem. The different forms and degrees of mixing of hydrothermal and seawater shape the highly heterogeneous hydrothermal habitat. For example, symbionts formed by microorganisms and fauna, chimneys, mats, plumes, sediments and other unique microbial communities. Although some studies have made important contributions to revealing some characteristics of hydrothermal vent microbial community, these studies pay more attention to local areas, and the understanding of global hydrothermal microbial diversity, geochemical element cycle drivers and interactions is not clear. This study selected hydrothermal data from the global deep-sea microbiome to explore how the metabolic network formed by hydrothermal microbial interaction mediates the biogeochemical cycle. The purpose is to gradually sort out and form the domain knowledge base of deep-sea habitat through the research strategy from local to overall, and explore and try to reveal the mechanism of carbon, nitrogen and sulfur cycle driven by deep-sea microbial community.