Greenlandic fjords connected to the Greenland Ice Sheet (GrIS) are at the forefront of climate change. Freshwater runoff from the GrIS has increased drastically since the late 1990s and is expected to continue to increase further under all future emission scenarios (IPCC shared socio-economic pathways). Here, we will present multiproxy and multisite reconstructions of environmental change in Nuup Kangerlua, the largest fjord system in west Greenland located by its capital, Nuuk. This fjord is one of the most productive in Greenland and includes both marine-terminating and land-terminating glaciers. We analyzed well dated sediment core records from the fjord spanning the Holocene (with focus on the modern warming period, the Little Ice Age, and the Holocene Thermal Maximum) to derive ecosystem responses to climate variability, particularly changes in marine (export) productivity and protist community structure from biogeochemical indicators (total organic carbon (TOC), nitrogen (TN), calcium carbonate (CaCO3), stable isotopes (13C and 15N), and biogenic silica (BSi) fluxes as well as diatom and dinoflagellate cyst analyses. We will discuss our findings in the context of freshwater runoff estimates from the GrIS and the wider regional climate and ocean variability.