Sedimentary oxygen consumption is one of the key process that constrains near bottom water hypoxia in estuaries and coasts. A better understanding of sedimentary oxygen consumpition is one of the essentials for hypoxia mechanisms study in the marine environment. In order to explore the controling factors in sediment oxygen consumption, we conduced series of incubations. The initial dissolved oxygen concentration of 20%, 40%, 60%, 80%, and 100% was set. During the 20% initial dissolved oxygen incubations, the dissolved oxygen concentration dropped from initial 51μmol/L to final 21μmol/L, resulting a dissolved oxygen consumption rate of 0.003μmol/L/h. As for 40%, 60%, 80% and 100% initial dissolved oxygen incubations, the dissolved oxygen consumption rate was 0.006μmol/L/h, 0.007μmol/L/h, 0.012μmol/L/h, and 0.015μmol/L/h, respectively. Pooled all the results together, we proved the positive relation between the sediment oxygen consumption rate and the initial dissolved oxygen concentration of the near bottom waters, with linear equation as y=0.0145x (r² = 0.9955). This strongly suggests the roles of water column dissolved oxygen concentration in determination of the sediment oxygen consumption. Good first-order kinetic equation between sediment oxygen consumption rate with initial dissolved oxygen concentration revealed that the sediment oxygen consumption rate followed the first-order kinetic model. The revelation of this law provides the theoretical basis for the future treatment of marine hypoxic zone, implying the complexity of low oxygen treatment by emphasizing the contribution and background role of sediment oxygen consumption. In hypoxia background, the sedimentary oxygen consumpition is expected to play a minor role as the dissolved oxygen in the water column was low. But in health conditoins (dissolved oxygen is high), sedimentary oxygen consumption is expected to be the key oxygen sink for the water column. Our work provides enlightenment for the management of coastal hypoxia in the estuaries and coasts.